Activation of signal transduction pathways during hepatic oncogenesis
نویسندگان
چکیده
منابع مشابه
Signal Transduction Pathways in Growth Control and Oncogenesis.
Normal cells have a series of molecular controls that prevents them from proliferating in the absence of essential environmental cues. These environmental cues include the presence of mitogenic growth factors and a suitable extracellular matrix (ECM). Cancer cells have lost these controls and thus can divide in the absence of these extracellular signals. We and others have examined how mitogeni...
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Metallothioneins are small, cysteine-rich, metal-binding proteins that play important roles in maintaining intracellular metal homeostasis and in transition metal detoxification. MTF-1 (metal transcription factor-1) plays a central role in regulating the metal-inducible, transcriptional activation of metallothionein. Here we report that the phosphorylation of MTF-1 plays a critical role in the ...
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ژورنال
عنوان ژورنال: Cancer Letters
سال: 2016
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2015.09.016